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6 juli, 2015 in

By Tideman Media

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    Related posts:

    Recent Posts

    Water intake calculator

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    —

    How Long Will It Take?

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    | **Topic** | **Key Points** |
    |———–|—————-|
    | **What is Anavar?** | A synthetic anabolic–androgenic steroid derived from dihydrotestosterone,
    used medically for weight gain and muscle wasting. |
    | **Medical Uses** | – Treats severe protein‑losing conditions (e.g., cachexia)
    – Promotes recovery after surgery or trauma
    – Improves bone density in osteoporotic patients |
    | **Legal Status** | Prescription only in the United States; banned by most sporting bodies.
    |
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    – Elevated liver enzymes
    – Mood changes
    – Potential cardiovascular effects |
    | **Why It’s Popular for Performance Enhancement** | Low androgenic side‑effect
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    |

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    **Reality Check:**

    | Claim | Scientific Basis |
    |——-|——————|
    | **Increases protein synthesis → larger muscle
    fibers** | Testosterone and its derivatives do stimulate satellite‑cell activity and mTOR‑mediated protein synthesis, but the magnitude of hypertrophy is modest (~5–15 % in trained athletes after 8–12 weeks).
    |
    | **Results in dramatic size increase within a few weeks** | Even with high anabolic steroids, muscle growth takes months.
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    |
    | **Works the same on untrained vs. trained individuals** | Untrained
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    |

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    —

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    ### Mechanism of Action

    | Step | What Happens? |
    |——|—————|
    | **1. Hormone Binding** | The steroid (e.g., testosterone enanthate)
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    on muscle cells. |
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    | **5. Metabolic Changes** | Hormones also stimulate glucose uptake, glycogen storage,
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    |

    #### 3.2 The Role of Testosterone in Male Development

    Testosterone is the principal androgen responsible for the development
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    in various tissues.

    ##### 3.2.1 Primary Effects on Growth and Strength

    | Tissue | Testosterone Effect | Mechanism |
    |——–|———————-|———–|
    | Muscles | ↑ protein synthesis, satellite cell activation |
    Direct genomic action via AR; non-genomic signaling |
    | Bones | ↑ osteoblast activity, bone mineral density
    | Modulation of calcium metabolism, indirect through growth hormone |
    | Fat | ↓ adiposity (particularly visceral) |
    Inhibition of lipogenesis, stimulation of thermogenesis |

    ##### 3.2.2 Secondary Effects on Hormonal Balance

    – **Suppression of GnRH/FSH/LH**: Negative feedback reduces
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    – **Inhibition of Aromatase**: Decreases conversion of testosterone to estradiol.

    – **Impact on Thyroid Hormones**: Potential modulation via
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    —

    ## 4. Interaction with the Immune System

    ### 4.1 Modulation of Cytokine Production

    Exogenous testosterone has been shown to shift
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    | Cytokine | Effect of Testosterone |
    |———-|————————|
    | IL-6 | ↓ (anti‑inflammatory) |
    | TNF‑α | ↓ (pro‑inflammatory) |
    | IL-10 | ↑ (immunosuppressive) |

    ### 4.2 Regulation of T‑Cell Differentiation

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    – Suppresses Th1 cytokines → reduced cell‑mediated immunity.

    ### 4.3 Impact on NK Cell Activity

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    – ↓ Natural Killer (NK) cell cytotoxicity.

    – ↓ Cytokine secretion (e.g., IFN‑γ).

    These effects can lead to a diminished innate immune response against viral infections.

    —

    ## Practical Implications

    | Situation | Potential Effect of Exogenous Testosterone
    |
    |———–|——————————————–|
    | **Athletes** training at high intensity | Possible reduction in NK
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    |
    | **Military personnel** in combat or prolonged stress |
    Decreased innate immune function could increase susceptibility to infections,
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    | **Individuals on testosterone therapy for medical conditions** |
    Monitoring of immune markers may be warranted; prophylactic measures
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    |

    —

    ## Take‑Home Messages

    1. **Testosterone can dampen certain components of innate immunity**, particularly NK cell activity and cytokine production.
    2. **The effect is dose‑dependent**: physiological levels
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    4. **Monitoring and preventive strategies**—such as ensuring up‑to‑date vaccinations and maintaining good hygiene—are
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    Feel free to dive deeper into specific pathways or
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